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SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
2
Erectile dysfunction unaffected by vitamin D
The effect of three years of vitamin D supplementation on erectile dysfunction: Results from the randomized placebo-controlled D-Health Trial.
Highly relevant exploratory analysis
We aimed to understand how vitamin D3 supplementation affects erectile dysfunction among older men, drawing from data collected in the large D-Health Trial. This study involved Australian men aged 60 to 84, who were randomly assigned to receive either 60,000 IU of vitamin D or a placebo each month for up to five years.
After three years, blood tests showed significant differences in vitamin D levels between the two groups, with those receiving vitamin D averaging around 106 nmol/L compared to 76 nmol/L in the placebo group. However, despite these differences, we observed no significant change in erectile dysfunction prevalence. The rates were nearly identical, with about 58.8% in the vitamin D group and 59.0% in the placebo group, indicating that vitamin D supplementation did not improve or prevent erectile dysfunction.
In our exploration, we found no evidence that vitamin D had any beneficial effect on erectile dysfunction, regardless of the participants' characteristics. Thus, it appears that supplementing older men with vitamin D might not lead to any improvements in this area.
After three years, blood tests showed significant differences in vitamin D levels between the two groups, with those receiving vitamin D averaging around 106 nmol/L compared to 76 nmol/L in the placebo group. However, despite these differences, we observed no significant change in erectile dysfunction prevalence. The rates were nearly identical, with about 58.8% in the vitamin D group and 59.0% in the placebo group, indicating that vitamin D supplementation did not improve or prevent erectile dysfunction.
In our exploration, we found no evidence that vitamin D had any beneficial effect on erectile dysfunction, regardless of the participants' characteristics. Thus, it appears that supplementing older men with vitamin D might not lead to any improvements in this area.
Read More
9
Vitamin D3 aids erectile recovery
Vitamin D3 improved erectile function recovery by regulating autophagy and apoptosis in a rat model of cavernous nerve injury.
Directly addresses erectile dysfunction.
We delved into how vitamin D3 may help improve erectile function, particularly after nerve injuries, by conducting a study involving eighteen male Sprague-Dawley rats. The rats were divided into three groups: one group acted as a control, another experienced bilateral cavernous nerve crush (BCNC) to simulate injury, and the last group received vitamin D treatment alongside the nerve injury.
Our findings suggested that vitamin D3 significantly improved the recovery of erectile function in the rats who had experienced nerve damage. We observed a reduction in hypoxia and a suppression of fibrosis, which are contributing factors to erectile dysfunction. Specifically, vitamin D3 appeared to enhance essential proteins that promote blood flow and reduce harmful fibrosis markers in the penile tissues.
Moreover, vitamin D3 fostered a healthier cellular environment by encouraging autophagy, a process that helps cells eliminate waste and regenerate. It also showed promise in reducing apoptosis, the process of programmed cell death, which often negatively impacts recovery. We found notable changes in specific protein expressions associated with these processes, further supporting the beneficial role of vitamin D3 in restoring erectile function after nerve injury.
In summary, vitamin D3 appears to hold potential as a therapeutic option for improving erectile function recovery in cases of nerve injury, thanks to its effects on hypoxia, fibrosis, autophagy, and apoptosis.
Our findings suggested that vitamin D3 significantly improved the recovery of erectile function in the rats who had experienced nerve damage. We observed a reduction in hypoxia and a suppression of fibrosis, which are contributing factors to erectile dysfunction. Specifically, vitamin D3 appeared to enhance essential proteins that promote blood flow and reduce harmful fibrosis markers in the penile tissues.
Moreover, vitamin D3 fostered a healthier cellular environment by encouraging autophagy, a process that helps cells eliminate waste and regenerate. It also showed promise in reducing apoptosis, the process of programmed cell death, which often negatively impacts recovery. We found notable changes in specific protein expressions associated with these processes, further supporting the beneficial role of vitamin D3 in restoring erectile function after nerve injury.
In summary, vitamin D3 appears to hold potential as a therapeutic option for improving erectile function recovery in cases of nerve injury, thanks to its effects on hypoxia, fibrosis, autophagy, and apoptosis.
Read More
7
Vitamin D's role in ED
Novel predictive risk factor of erectile dysfunction: Serum 25-hydroxy vitamin D.
Study highlights vitamin D importance
We examined the connection between vitamin D levels and erectile dysfunction (ED) in a group of 130 men who experienced this issue from 2018 to 2019. Participants were categorized into three groups based on their erectile function scores using a standardized questionnaire.
Our findings revealed significant differences in serum 25-hydroxy vitamin D levels among these groups. Those with severe ED had notably lower levels of vitamin D compared to those with moderate and mild dysfunction. We discovered a positive relationship between vitamin D levels, testosterone, and erectile function scores.
Based on the results, we determined a cut-off level of 27.32 ng/ml for serum vitamin D. This suggests that lower vitamin D levels may contribute to poorer erectile function. Consequently, vitamin D replacement therapy might help alleviate symptoms of ED, presenting a potential avenue for treatment.
Overall, our research points to the importance of monitoring vitamin D levels in men with erectile dysfunction and suggests that addressing vitamin D deficiency could improve their condition.
Our findings revealed significant differences in serum 25-hydroxy vitamin D levels among these groups. Those with severe ED had notably lower levels of vitamin D compared to those with moderate and mild dysfunction. We discovered a positive relationship between vitamin D levels, testosterone, and erectile function scores.
Based on the results, we determined a cut-off level of 27.32 ng/ml for serum vitamin D. This suggests that lower vitamin D levels may contribute to poorer erectile function. Consequently, vitamin D replacement therapy might help alleviate symptoms of ED, presenting a potential avenue for treatment.
Overall, our research points to the importance of monitoring vitamin D levels in men with erectile dysfunction and suggests that addressing vitamin D deficiency could improve their condition.
Read More
Most Useful Reviews
8.8
Vitamin D benefits
Dee recommends this vitamin D supplement as I have limited sun exposure and struggle with vitamin D production. I've chosen the 5000IU dosage because excessive vitamin D may cause kidney dysfunction, which is a concern I take seriously.
Read More
9.5
Bone health impact
I understand that vitamin D deficiency can lead to serious health issues such as osteomalacia in adults and rickets in children. As a fat-soluble vitamin, too much can cause problems like hypercalcemia. I appreciate vitamin D in foods like mushrooms and seafood.
Read More
8.8
Improved health
I take two capsules of vitamin D twice daily after blood tests indicated a deficiency. Over time, I've started to feel better, particularly regarding my erectile dysfunction. I believe the quality of the product is good, and I would recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
9
Vitamin D3 aids erectile recovery
Vitamin D3 improved erectile function recovery by regulating autophagy and apoptosis in a rat model of cavernous nerve injury.
Directly addresses erectile dysfunction.
We delved into how vitamin D3 may help improve erectile function, particularly after nerve injuries, by conducting a study involving eighteen male Sprague-Dawley rats. The rats were divided into three groups: one group acted as a control, another experienced bilateral cavernous nerve crush (BCNC) to simulate injury, and the last group received vitamin D treatment alongside the nerve injury.
Our findings suggested that vitamin D3 significantly improved the recovery of erectile function in the rats who had experienced nerve damage. We observed a reduction in hypoxia and a suppression of fibrosis, which are contributing factors to erectile dysfunction. Specifically, vitamin D3 appeared to enhance essential proteins that promote blood flow and reduce harmful fibrosis markers in the penile tissues.
Moreover, vitamin D3 fostered a healthier cellular environment by encouraging autophagy, a process that helps cells eliminate waste and regenerate. It also showed promise in reducing apoptosis, the process of programmed cell death, which often negatively impacts recovery. We found notable changes in specific protein expressions associated with these processes, further supporting the beneficial role of vitamin D3 in restoring erectile function after nerve injury.
In summary, vitamin D3 appears to hold potential as a therapeutic option for improving erectile function recovery in cases of nerve injury, thanks to its effects on hypoxia, fibrosis, autophagy, and apoptosis.
Our findings suggested that vitamin D3 significantly improved the recovery of erectile function in the rats who had experienced nerve damage. We observed a reduction in hypoxia and a suppression of fibrosis, which are contributing factors to erectile dysfunction. Specifically, vitamin D3 appeared to enhance essential proteins that promote blood flow and reduce harmful fibrosis markers in the penile tissues.
Moreover, vitamin D3 fostered a healthier cellular environment by encouraging autophagy, a process that helps cells eliminate waste and regenerate. It also showed promise in reducing apoptosis, the process of programmed cell death, which often negatively impacts recovery. We found notable changes in specific protein expressions associated with these processes, further supporting the beneficial role of vitamin D3 in restoring erectile function after nerve injury.
In summary, vitamin D3 appears to hold potential as a therapeutic option for improving erectile function recovery in cases of nerve injury, thanks to its effects on hypoxia, fibrosis, autophagy, and apoptosis.
Read More
9
Vitamin D3 aids erectile dysfunction
The effect of vitamin D replacement in patients with lower urinary tract complaint/erectile dysfunction resistant to Tadalafil 5 mg treatment: A pilot clinical study.
Relevance score indicates treatment significance
We aimed to find out how vitamin D3 replacement affects men experiencing erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) who weren't benefiting from daily tadalafil treatment. Over a period from September 2017 to August 2020, we included patients who had been taking 5 mg of tadalafil for at least a month without significant improvement.
After establishing their vitamin D levels, we treated those with low vitamin D (below 20 ng/ml) with a weekly oral dose of 100,000 IU for one month, while they continued taking tadalafil. We measured their erectile function and urinary symptom scores before and after the treatment.
The results were promising; after the vitamin D supplementation, there was a significant improvement in erectile function and urinary symptoms, illustrating the potential benefits of checking and addressing vitamin D deficiency in men whose condition doesn't respond to conventional ED treatments. This suggests that vitamin D might play an essential role in enhancing treatment responses.
After establishing their vitamin D levels, we treated those with low vitamin D (below 20 ng/ml) with a weekly oral dose of 100,000 IU for one month, while they continued taking tadalafil. We measured their erectile function and urinary symptom scores before and after the treatment.
The results were promising; after the vitamin D supplementation, there was a significant improvement in erectile function and urinary symptoms, illustrating the potential benefits of checking and addressing vitamin D deficiency in men whose condition doesn't respond to conventional ED treatments. This suggests that vitamin D might play an essential role in enhancing treatment responses.
Read More
9
Vitamin D3 may enhance erectile function
Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency?
Study highlights vitamin D effectiveness.
The research focused on understanding the impact of vitamin D3 when added to tadalafil treatment in patients suffering from erectile dysfunction (ED) and vitamin D deficiency (VDD). We examined 111 patients over a few years, dividing them into two groups: one group received only tadalafil, while the other received both tadalafil and vitamin D3.
At the end of our evaluation, we noted positive outcomes in both groups concerning erectile function and sexual satisfaction. However, the group that received vitamin D3 alongside tadalafil showed even greater improvements, particularly in erectile function and sexual desire, compared to the group that only received tadalafil.
This suggests that for those who have both ED and low vitamin D levels, adding vitamin D3 could enhance treatment effectiveness. Overall, the findings encourage consideration of vitamin D supplementation in managing erectile dysfunction, especially for patients with a deficiency.
At the end of our evaluation, we noted positive outcomes in both groups concerning erectile function and sexual satisfaction. However, the group that received vitamin D3 alongside tadalafil showed even greater improvements, particularly in erectile function and sexual desire, compared to the group that only received tadalafil.
This suggests that for those who have both ED and low vitamin D levels, adding vitamin D3 could enhance treatment effectiveness. Overall, the findings encourage consideration of vitamin D supplementation in managing erectile dysfunction, especially for patients with a deficiency.
Read More
7
Vitamin D impacts erectile dysfunction
The relationship between serum 25-hydroxy vitamin D and arteriogenic erectile dysfunction.
Study assesses vitamin D and ED
We set out to uncover the relationship between vitamin D levels and erectile dysfunction (ED), particularly focusing on arteriogenic erectile dysfunction (A-ED). In our study conducted from September 2020 to January 2022, we assessed 150 patients diagnosed with ED using the International Index of Erectile Function-5 (IIEF-5) questionnaire.
The patients classified as suffering from organic ED underwent further examination through nocturnal penile tumescence and rigidity (NPTR) tests, as well as penile Doppler ultrasound (PDU) to distinguish between A-ED and non-arteriogenic ED (NA-ED).
Our findings showed that vitamin D levels, specifically 25-hydroxy vitamin D (25[OH]D), were significantly lower in those with organic ED compared to those with psychological ED. Notably, patients with A-ED had dramatically lower vitamin D levels and peak systolic flow velocity (PSV) measurements compared to those with NA-ED.
Moreover, we noted a positive correlation between 25(OH)D levels and IIEF-5 scores, as well as PSV values in A-ED patients. This suggests that low vitamin D levels may be a significant risk factor for arteriogenic ED. Hence, we recommend that all ED patients should be tested for serum 25(OH)D levels and consider vitamin D replacement therapy if their levels are found to be low.
The patients classified as suffering from organic ED underwent further examination through nocturnal penile tumescence and rigidity (NPTR) tests, as well as penile Doppler ultrasound (PDU) to distinguish between A-ED and non-arteriogenic ED (NA-ED).
Our findings showed that vitamin D levels, specifically 25-hydroxy vitamin D (25[OH]D), were significantly lower in those with organic ED compared to those with psychological ED. Notably, patients with A-ED had dramatically lower vitamin D levels and peak systolic flow velocity (PSV) measurements compared to those with NA-ED.
Moreover, we noted a positive correlation between 25(OH)D levels and IIEF-5 scores, as well as PSV values in A-ED patients. This suggests that low vitamin D levels may be a significant risk factor for arteriogenic ED. Hence, we recommend that all ED patients should be tested for serum 25(OH)D levels and consider vitamin D replacement therapy if their levels are found to be low.
Read More
7
Vitamin D's role in ED
Novel predictive risk factor of erectile dysfunction: Serum 25-hydroxy vitamin D.
Study highlights vitamin D importance
We examined the connection between vitamin D levels and erectile dysfunction (ED) in a group of 130 men who experienced this issue from 2018 to 2019. Participants were categorized into three groups based on their erectile function scores using a standardized questionnaire.
Our findings revealed significant differences in serum 25-hydroxy vitamin D levels among these groups. Those with severe ED had notably lower levels of vitamin D compared to those with moderate and mild dysfunction. We discovered a positive relationship between vitamin D levels, testosterone, and erectile function scores.
Based on the results, we determined a cut-off level of 27.32 ng/ml for serum vitamin D. This suggests that lower vitamin D levels may contribute to poorer erectile function. Consequently, vitamin D replacement therapy might help alleviate symptoms of ED, presenting a potential avenue for treatment.
Overall, our research points to the importance of monitoring vitamin D levels in men with erectile dysfunction and suggests that addressing vitamin D deficiency could improve their condition.
Our findings revealed significant differences in serum 25-hydroxy vitamin D levels among these groups. Those with severe ED had notably lower levels of vitamin D compared to those with moderate and mild dysfunction. We discovered a positive relationship between vitamin D levels, testosterone, and erectile function scores.
Based on the results, we determined a cut-off level of 27.32 ng/ml for serum vitamin D. This suggests that lower vitamin D levels may contribute to poorer erectile function. Consequently, vitamin D replacement therapy might help alleviate symptoms of ED, presenting a potential avenue for treatment.
Overall, our research points to the importance of monitoring vitamin D levels in men with erectile dysfunction and suggests that addressing vitamin D deficiency could improve their condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Bone health impact
I understand that vitamin D deficiency can lead to serious health issues such as osteomalacia in adults and rickets in children. As a fat-soluble vitamin, too much can cause problems like hypercalcemia. I appreciate vitamin D in foods like mushrooms and seafood.
8.8
Vitamin D benefits
Dee recommends this vitamin D supplement as I have limited sun exposure and struggle with vitamin D production. I've chosen the 5000IU dosage because excessive vitamin D may cause kidney dysfunction, which is a concern I take seriously.
8.8
Improved health
I take two capsules of vitamin D twice daily after blood tests indicated a deficiency. Over time, I've started to feel better, particularly regarding my erectile dysfunction. I believe the quality of the product is good, and I would recommend it.
